![]() Values: The evidence-based methods and values of the Canadian Task Force on the Periodic Health Examination were used. 31, 1994, with the use of MeSH terms 'Down syndrome,' 'prenatal diagnosis,' 'screening,' 'prevention,' 'amniocentesis,' 'chorionic villus sampling,' 'ultrasonography,' 'anxiety,' 'depression' and 'psychological stress' and a manual search of bibliographies, recent issues of key journals and Current Contents. Evidence: A MEDLINE search for relevant articles published from Jan. Outcomes: Accuracy of detection of DS in fetuses and risks to the mother, including psychologic distress, and to the Fetus from the screening and diagnostic interventions. Options: 'Triple-marker' screening of maternal serum levels of α-fetoprotein, human chorionic gonadotropin and unconjugated estriol, fetal ultrasonographic examination, amniocentesis, and chorionic villus sampling (CVS). Objective: To make recommendations to physicians providing prenatal care on (1) whether prenatal screening for and diagnosis of Down syndrome (DS) is advisable and (2) alternative screening and diagnosis manoeuvres. ![]()
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